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Table 4 Citrate synthase activity, and complex I- and II-dependent oxidative phosphorylation in PBMC and CK in plasma of CFS patients and controls before CPET1 and CPET2&

From: Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity

  CPET1 CPET2
  Patients n = 15 Controls n = 15 Patients n = 15 Controls n = 15
Citrate synthase (CS) U/g protein 135 ± 61 132 ± 17 128 ± 20 154 ± 51
ATP synthesis via Complex I nmol/(0.5 h. mg protein) 7.1 ± 3.1 7.8 ± 2.8 6.7 ± 4.8 9.5 ± 5.7
ATP synthesis via Complex I nmol/(0.5 h. U CS) 54 ± 19 58 ± 21 54 ± 34 61 ± 26
ATP synthesis via Complex II nmol/(0.5 h. mg protein) 7.8 ± 5.0 8.2 ± 2.8 6.8 ± 4.9 8.9 ± 5.3
ATP synthesis via Complex II nmol/(0.5 h. U CS) 58 ± 22 60 ± 26 54 ± 36 58 ± 27
CK in plasma U/L 70 ± 25 83 ± 35 64 ± 22 96 ± 63
  1. & Data are presented as mean ± SD
  2. There were no statistically significant differences between patients and controls at CPET1 or 2 (according to multivariate ANOVA), or between CEPT1 and 2 for patients or for controls (according to repeated measures ANOVA)