Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity

Table 4 Citrate synthase activity, and complex I- and II-dependent oxidative phosphorylation in PBMC and CK in plasma of CFS patients and controls before CPET1 and CPET2^&

	CPET1		CPET2
	Patients n = 15	Controls n = 15	Patients n = 15	Controls n = 15
Citrate synthase (CS) U/g protein	135 ± 61	132 ± 17	128 ± 20	154 ± 51
ATP synthesis via Complex I nmol/(0.5 h. mg protein)	7.1 ± 3.1	7.8 ± 2.8	6.7 ± 4.8	9.5 ± 5.7
ATP synthesis via Complex I nmol/(0.5 h. U CS)	54 ± 19	58 ± 21	54 ± 34	61 ± 26
ATP synthesis via Complex II nmol/(0.5 h. mg protein)	7.8 ± 5.0	8.2 ± 2.8	6.8 ± 4.9	8.9 ± 5.3
ATP synthesis via Complex II nmol/(0.5 h. U CS)	58 ± 22	60 ± 26	54 ± 36	58 ± 27
CK in plasma U/L	70 ± 25	83 ± 35	64 ± 22	96 ± 63

^& Data are presented as mean ± SD
There were no statistically significant differences between patients and controls at CPET1 or 2 (according to multivariate ANOVA), or between CEPT1 and 2 for patients or for controls (according to repeated measures ANOVA)

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