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Table 1 Effect of S110 on γ-globin expression in human erythroid progenitor cell cultures.

From: S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)

Treatment

Dose (μM)

γ/γ + β

mRNA

γ/γ + β

polypeptide chain ratio

Control

0

0.162 ± .091 (n = 4)

18.3 ± 3.3 (n = 3)

Decitabine

1

0.337 ± .135 (n = 4)

29.8 ± 3.2 (n = 3)

S110

1

0.355 ± .038 (n = 4)

27.8 ± 1.9 (n = 3)

S110

5

0.310 ± .136 (n = 3)

29.2 ± 2.9 (n = 3)

  1. The effect of decitabine and S110 on globin mRNA (n = 4) and globin chain expression (n = 3) was measured in cultured human erythroid progenitor cells. Difference in γ/γ+β mRNA and γ/γ+β chain ratios between untreated controls and drug-treated cultures was significant (p < .05)