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Table 1 Effect of S110 on γ-globin expression in human erythroid progenitor cell cultures.

From: S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)

Treatment Dose (μM) γ/γ + β
mRNA
γ/γ + β
polypeptide chain ratio
Control 0 0.162 ± .091 (n = 4) 18.3 ± 3.3 (n = 3)
Decitabine 1 0.337 ± .135 (n = 4) 29.8 ± 3.2 (n = 3)
S110 1 0.355 ± .038 (n = 4) 27.8 ± 1.9 (n = 3)
S110 5 0.310 ± .136 (n = 3) 29.2 ± 2.9 (n = 3)
  1. The effect of decitabine and S110 on globin mRNA (n = 4) and globin chain expression (n = 3) was measured in cultured human erythroid progenitor cells. Difference in γ/γ+β mRNA and γ/γ+β chain ratios between untreated controls and drug-treated cultures was significant (p < .05)