From: S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)
Treatment | Dose (μM) | γ/γ + β mRNA | γ/γ + β polypeptide chain ratio |
---|---|---|---|
Control | 0 | 0.162 ± .091 (n = 4) | 18.3 ± 3.3 (n = 3) |
Decitabine | 1 | 0.337 ± .135 (n = 4) | 29.8 ± 3.2 (n = 3) |
S110 | 1 | 0.355 ± .038 (n = 4) | 27.8 ± 1.9 (n = 3) |
S110 | 5 | 0.310 ± .136 (n = 3) | 29.2 ± 2.9 (n = 3) |