cDNA targets improve whole blood gene expression profiling and enhance detection of pharmocodynamic biomarkers: a quantitative platform analysis

Table 1 Quantitative assessment of globin interference and tissue-specific signatures.

	Probesets Correlated to globin (p-value < 0.01)	Tissue specific probesets FDR = 10% ** (critical p-value)	Standard Deviation of intensity for globin-correlated genes	Power ⁺⁺
No Treatment	23290	97 (2e-4)	0.36	11%
PNA	15912	117 (2e-4)	0.30	18%
cDNA	1799	2597 (3e-3)	0.12	90%

Globin Related genes are those that have a significant correlation in expression magnitude to the amount of globin in each sample. Tissue Specific genes are those that are associated to a 1% brain vs. 1% liver expression pattern. Standard Deviation refers to the variability in globin interference genes correlated to the variation in globin content.
** Critical p-value is in parenthesis
++ Power to detect 1.4 fold change at p-value = 0.01, 4 samples per group

ISSN: 1479-5876