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Figure 6 | Journal of Translational Medicine

Figure 6

From: cDNA targets improve whole blood gene expression profiling and enhance detection of pharmocodynamic biomarkers: a quantitative platform analysis

Figure 6

Receiver Operator Characteristic curves of 1% brain vs 1% liver signature detection. The total number of genes detected by a t-test at a specific p-value are plotted against the number of false positive genes detected at the same p-value. False positives were calculated using permutations controlled for equal number of liver and brain samples in each group. ROC analysis was done as follows: the true positive rate was estimated using a t-test between liver and brain spike-in samples; false positive rate was estimated using t-test after permutation of sample indexes. Permutation is constrained so that each group has equal number of liver and brain spiked samples. This will ensure that false positive rate is not inflated by biological differences.

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