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Table 2 Information of the tumor suppressor genes analyzed.

From: Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer

Gene Namea Probes Functional implications Chromosomal Localizationb
PRDM2 PR domain containing 2, with ZNF domain 09146-L02862 Cell cycle control 1p36
RUNX3 Runt-related transcription factor 3 11131-L03905 TGFB signaling 1p36
RARB Retinoic acid receptor beta 10362-L10900 Cell differentiation and proliferation 3p24
HLTF Helicase-like transcription factor 09152-L09384(probe 1) 02758-L02207(probe 2) Transcription regulation 3q25.1-q26.1
SCGB3A1 Secretoglobin, family 3A, member 1 03305-L09382 (probe1) 11132-L12956(probe 2) Cell differentiation and proliferation 5q35-qter
ID4 Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 04497-L03909(probe 1) 04496-L03908(probe 2) Transcription regulation 6p22.3
TWIST1 Twist homolog 1 (Drosophila) 02080-L02886 Cell differentiation and proliferation 7p21
SFRP4 Secreted frizzled-related protein 4 03744-L03204(probe 1) 09147-L03205(probe 2) WNT antagonism 7p14.1
DLC1 Deleted in liver cancer 1 02754-L02203(probe 1) 02753-L02202(probe 2) Cell differentiation and proliferation 8p22
SFRP5 Secreted frizzled-related protein 5 09149-L03207(probe 1) 09148-L12957(probe 2) WNT antagonism 10q24
BNIP3 BCL2/adenovirus E1B 19kDa Interacting protein 3 07138-L12958 Proliferation and apoptosis 10q.26.3
H2AFX H2A histone family, member X 08511-L08607(probe 1) 08509-L08605(probe 2) Transcription regulation 11q23.3
CCND2 Cyclin D2 03313-L02668(probe 1) 03312-L09381(probe 2) Cell cycle control 12p13
CACNA1G Calcium channel, voltage-dependent, T type, alpha 1G subunit 10123-L10466 Cell differentiation and proliferation 17q22
TGIF TGFB-induced factor homebox 1 02850-L13256 TGFB signaling 18p11.31
BCL2 B-cell CLL/lymphoma2 10352-L10890 Proliferation and apoptosis 18q21.3
CACNA1A Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 09055-L09224 Cell differentiation and proliferation 19p13
TIMP3 TIMP metallopeptidase inhibitor 3 10357-L10895(probe 1) 10354-L10892(probe 2) Invasion and metastasis 22q12.3
  1. Summary of the gene description, probes, functional implications, and chromosomal location of the tumor suppressor genes analyzed in this study.
  2. Gene names in bold highlight novel candidates never reported to be methylated in lung cancer to date. a. Human Genome Organization Nomenclature; b. Approved gene name from Human Genome Organization available at http://www.genenames.org/