Table 2 Information of the tumor suppressor genes analyzed.
From: Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer
Gene | Namea | Probes | Functional implications | Chromosomal Localizationb |
|---|---|---|---|---|
PRDM2 | PR domain containing 2, with ZNF domain | 09146-L02862 | Cell cycle control | 1p36 |
RUNX3 | Runt-related transcription factor 3 | 11131-L03905 | TGFB signaling | 1p36 |
RARB | Retinoic acid receptor beta | 10362-L10900 | Cell differentiation and proliferation | 3p24 |
HLTF | Helicase-like transcription factor | 09152-L09384(probe 1) 02758-L02207(probe 2) | Transcription regulation | 3q25.1-q26.1 |
SCGB3A1 | Secretoglobin, family 3A, member 1 | 03305-L09382 (probe1) 11132-L12956(probe 2) | Cell differentiation and proliferation | 5q35-qter |
ID4 | Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 04497-L03909(probe 1) 04496-L03908(probe 2) | Transcription regulation | 6p22.3 |
TWIST1 | Twist homolog 1 (Drosophila) | 02080-L02886 | Cell differentiation and proliferation | 7p21 |
SFRP4 | Secreted frizzled-related protein 4 | 03744-L03204(probe 1) 09147-L03205(probe 2) | WNT antagonism | 7p14.1 |
DLC1 | Deleted in liver cancer 1 | 02754-L02203(probe 1) 02753-L02202(probe 2) | Cell differentiation and proliferation | 8p22 |
SFRP5 | Secreted frizzled-related protein 5 | 09149-L03207(probe 1) 09148-L12957(probe 2) | WNT antagonism | 10q24 |
BNIP3 | BCL2/adenovirus E1B 19kDa Interacting protein 3 | 07138-L12958 | Proliferation and apoptosis | 10q.26.3 |
H2AFX | H2A histone family, member X | 08511-L08607(probe 1) 08509-L08605(probe 2) | Transcription regulation | 11q23.3 |
CCND2 | Cyclin D2 | 03313-L02668(probe 1) 03312-L09381(probe 2) | Cell cycle control | 12p13 |
CACNA1G | Calcium channel, voltage-dependent, T type, alpha 1G subunit | 10123-L10466 | Cell differentiation and proliferation | 17q22 |
TGIF | TGFB-induced factor homebox 1 | 02850-L13256 | TGFB signaling | 18p11.31 |
BCL2 | B-cell CLL/lymphoma2 | 10352-L10890 | Proliferation and apoptosis | 18q21.3 |
CACNA1A | Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 09055-L09224 | Cell differentiation and proliferation | 19p13 |
TIMP3 | TIMP metallopeptidase inhibitor 3 | 10357-L10895(probe 1) 10354-L10892(probe 2) | Invasion and metastasis | 22q12.3 |