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Figure 3 | Journal of Translational Medicine

Figure 3

From: Adenoviruses with an αvβ integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases

Figure 3

Cell killing potency of RGD modified viruses in vitro. Viruses with RGD modification in the capsid display effective killing of colorectal cancer cell lines. Cells were infected with replication competent (WT-RGD, WT-RGDK, WT) or non-replicating (Ad5luc1) viruses and the cell killing potency was assessed with the MTS assay. Data are presented as relative cell viability normalized to mock (growth medium) infected cells. Each data point represents the mean of six replicates ± SEM.

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