Biodistribution of adenoviral vectors with RGD modification in the capsid. Mice bearing intrasplenic and intrahepatic tumors were injected via tail vein with 3 × 10e10 VP and organs/tumors were harvested two days later. The number of 5 animals was treated in each group. (A) Luciferase expression of organs was analyzed. Data are presented as relative light units (RLU) after normalization for protein concentration. Each bar represents mean ± SEM. (B) Spleen tumor to normal spleen ratio of transgene expression. (C) Liver tumor to normal liver ratio of transgene expression. *, p < 0.05; **, p < 0.01.