Figure 2From: Adenoviruses with an αvβ integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastasesBiodistribution of adenoviral vectors with RGD modification in the capsid. Mice bearing intrasplenic and intrahepatic tumors were injected via tail vein with 3 × 10e10 VP and organs/tumors were harvested two days later. The number of 5 animals was treated in each group. (A) Luciferase expression of organs was analyzed. Data are presented as relative light units (RLU) after normalization for protein concentration. Each bar represents mean ± SEM. (B) Spleen tumor to normal spleen ratio of transgene expression. (C) Liver tumor to normal liver ratio of transgene expression. *, p < 0.05; **, p < 0.01.Back to article page