Figure 2

Comparison of regulatory T cell levels at baseline in patients with melanoma and healthy subjects. (A) Box plot showing baseline regulatory T cell (Treg) levels in 22 patients with melanoma prior to interferon-α 2b (IFN-α 2b) treatment compared with 20 healthy subjects (HS) (P = 0.001). (B) Box plot showing Treg levels by disease stage in 20 healthy subjects and 44 patients with melanoma (P < 0.01 for increased Tregs in all melanoma patients vs. healthy subjects); P = not significant for Treg increase by disease stage. Horizontal lines inside the boxes = median values; upper and lower boundaries of the boxes = first and third quartiles of the distribution; whiskers = mild outliers; open dots = outliers; and asterisks = extreme outliers.