Table 1 Different doxycycline treatment schemes, including duration of treatment, concentrations and mice models used
Treatment period | Dose (mg/Kg/day) | strain | Age (months) | Treatment MMP-9 positive | Control MMP-9 positive | Treatment CR positive | Control CR positive |
|---|---|---|---|---|---|---|---|
1 month | 40 | TTR/HSF | 19 | 2/10 | 6/8 | 0/10 | 5/10 |
15 days | 40 | TTR/HSF | 26 | 2/10 | 7/8 | 2/10 | 3/7 |
15 days + 45 days interruption | 40 | TTR/HSF | 20 | 8/10 | 6/8 | 5/10 | 4/8 |
15 days + 30 days interruption | 40 | TTR/HSF | 23-25 | 0/10 | 10/10 | 0/10 | 8/10 |
15 days | 8 | TTR/HSF | 16-18 | 1/7 | 9/10 | 1/7 | 8/10 |
15 days + 30 days interruption | 8 | TTR/HSF | 16-18 | 8/12 | 4/4 | 7/12 | 3/7 |
15 days + 15 days interruption | 8 | TTR/HSF | 20 | 4/10 | 7/8 | 1/10 | 4/8 |
15 days + 15 days interruption | 8 | TTR | 22 | 2/15 | 6/8 | 2/15 | 4/8 |