Evaluation of normalization methods for two-channel microRNA microarrays

Table 1 Summary statistics for performance of different normalization methods based on intra-class correlations (ICC s) computed for replicate miR microarray data obtained using 10 different lung cancer cell lines

Methods	Min	Max	Median	Mean	SD
No.Norm	-0.03	0.82	0.55	0.51	0.25
Mean	-0.02	0.87	0.58	0.56	0.27
t.Mean	-0.02	0.87	0.58	0.56	0.27
Median	-0.06	0.87	0.56	0.54	0.27
Lowess	0.05	0.87	0.51	0.53	0.26
Quantile	0.17	0.78	0.54	0.52	0.18
Mean.10	-0.15	0.84	0.38	0.36	0.36
Mean.20	-0.05	0.86	0.55	0.54	0.28
Mean.30	-0.03	0.87	0.56	0.55	0.27
t.Mean.10	-0.15	0.84	0.38	0.36	0.36
t.Mean.20	-0.05	0.86	0.55	0.53	0.28
t.Mean.30	-0.02	0.87	0.56	0.55	0.27
Median.10	-0.21	0.86	0.36	0.35	0.39
Median.20	-0.11	0.87	0.56	0.54	0.29
Median.30	-0.07	0.87	0.57	0.55	0.28
Lowess.10	-0.30	0.73	0.16	0.23	0.35
Lowess.20	-0.06	0.85	0.37	0.42	0.30
Lowess.30	0.02	0.87	0.44	0.48	0.28
Quantile.10	0.24	0.86	0.62	0.60	0.20
Quantile.20	0.39	0.87	0.67	0.65	0.16
Quantile.30	0.38	0.85	0.63	0.62	0.18
Quantile.40	0.34	0.86	0.65	0.62	0.18

ISSN: 1479-5876