Figure 3

Example of time course-related changes in the abundances of spectral components. A - Individual time courses of changes in the abundance of spectral components registered at the approximate m/z value 9419 Da in samples collected from 70 patients at three time points (dots connected with black lines); blue lines represent the average for all patients. B - Box-plots represent quantification of differences in the abundance of the 9419 Da spectral component in samples collected for each of 70 patients between three time points; shown are minimum, lower quartile, median, upper quartile, maximum values and outlier marked with asterisk (q-values of the significance of differences were 0.856, 0.024 and 0.065 for B-A, C-B and C-A, respectively). C - Cluster that contained spectral components registered at approximate m/z values 4211, 6428 and 9419 Da. For each of three components shown are average intensities for samples collected from 70 patients at different time points (dots connected with black lines), the blue line represents averages for all components; the cluster represents [A≥B<C] type.