From: Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity
Gene Name | Monocytes | Resting | Â | LPS | Â |
---|---|---|---|---|---|
DEFB1 | Control | a1.1 ± 0.6 |  | 12.6 ± .0 |  |
 | up | = |  |  |  |
 | IRAK4 Q293X | 1.9 ± 0.9 |  | 9.6 ± 0.9 |  |
Fos | Control | 1.5 ± 0.1 |  | 0.3 ± 0.0 |  |
 | = | = |  |  |  |
 | IRAK4 Q293X | 1.3 ± 0.0 |  | 0.3 ± 0.1 |  |
Gro-α (CXCL1) | Control | 1.0 ± 0.2 |  | 6.3 ± 1.2 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.3 ± 0.0 |  | 0.3 ± 0.0 |  |
IL-6 | Control | 1.1 ± 0.6 |  | 185.4 ± 110.0 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.4 ± 0.5 |  | 1.8 ± 2.1 |  |
IL-8 | Control | 1.0 ± 0.0 |  | 24.1 ± 5.5 |  |
 | = | dn |  |  |  |
 | IRAK4 Q293X | 0.9 ± 0.8 |  | 2.0 ± 1.4 |  |
IL-12β | Control | 1.0 ± 0.4 |  | 181.7 ± 8.0 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.2 ± 0.1 |  | 1.9 ± 0.8 |  |
IL-13RA1 | Control | 1.0 ± 0.1 |  | 0.3 ± 0.0 |  |
 | = | up |  |  |  |
 | IRAK4 Q293X | 1.1 ± 0.3 |  | 1.9 ± 0.1 |  |
IFN-γ | Control | 1.0 ± 0.1 |  | 11.0 ± 0.3 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.4 ± 0.1 |  | 0.8 ± 0.3 |  |
IRF1 | Control | 1.0 ± 0.1 |  | 6.7 ± 0.1 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.6 ± 0.1 |  | 3.1 ± 0.2 |  |
IκBζ | Control | 1.1 ± 0.5 |  | 1.3 ± 0.3 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.4 ± 0.2 |  | 0.5 ± 0.1 |  |
Jun | Control | 1.0 ± 0.0 |  | 0.9 ± 0.2 |  |
 | = | up |  |  |  |
 | IRAK4 Q293X | 0.9 ± 0.3 |  | 1.7 ± 0.4 |  |
MCP-2 (CCL8) | Control | 1.0 ± 0.0 |  | 9.4 ± 0.0 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.1 ± 0.0 |  | 1.8 ± 0.2 |  |
MDC (CCL22) | Control | 1.1 ± 0.5 |  | 4.1 ± 1.2 |  |
 | dn | up |  |  |  |
 | IRAK4 Q293X | 0.6 ± 0.2 |  | 6.4 ± 1.8 |  |
MIP-3α (CCL20) | Control | 1.0 ± 0.2 |  | 83.9 ± 0.0 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.1 ± 0.0 |  | 1.4 ± 0.5 |  |
NFκB1 (p105/p50) | Control | 1.0 ± 0.1 |  | 6.8 ± 0.1 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.3 ± 0.1 |  | 2.3 ± 0.7 |  |
NFκB2 (p100/p52) | Control | 1.0 ± 0.0 |  | 4.5 ± 0.7 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.7 ± 0.0 |  | 1.9 ± 0.3 |  |
NFκB cRel | Control | 1.0 ± 0.1 |  | 3.8 ± 0.1 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.7 ± 0.0 |  | 1.0 ± 0.0 |  |
NFκB RelA (p65) | Control | 1.0 ± 0.0 |  | 3.3 ± 0.2 |  |
 | = | dn |  |  |  |
 | IRAK4 Q293X | 1.2 ± 0.0 |  | 2.3 ± 0.4 |  |
NFκB RelB | Control | 1.0 ± 0.2 |  | 1.9 ± 0.4 |  |
 | = | = |  |  |  |
 | IRAK4 Q293X | 0.8 ± 0.0 |  | 1.7 ± 0.3 |  |
SOCS1 | Control | 1.2 ± 0.8 |  | 21.2 ± 4.7 |  |
 | dn | dn |  |  |  |
 | IRAK4 Q293X | 0.1 ± 0.1 |  | 1.6 ± 0.5 |  |
TNF-α | Control | 1.0 ± 0.1 |  | 11.3 ± 4.0 |  |
 | = | dn |  |  |  |
 | IRAK4 Q293X | 0.9 ± 0.6 |  | 2.4 ± 0.7 |  |
ZFP36L2 | Control | 1.0 ± 0.1 |  | 0.8 ± 0.0 |  |
 | up | up |  |  |  |
 | IRAK4 Q293X | 2.1 ± 0.5 |  | 2.1 ± 0.2 |  |