Figure 4

Photomicrographs of histological sections from skin stained with a trichromic stain. A: Wound healing in zone with no implant system (N/IS). Epidermis (asterisk) free of hairs and a region of granulation tissue below (gt), flanked by bundles of hair follicles (arrowheads). B High magnification on the asterisk region from A; thicker epidermis (e) with more than 15 nucleated cell layers and granulation tissue with blood vessels. C: Wound healing in zone treated with CFIS (W/CFIS) Epidermis (asterisk) free of hairs. Bulky granulation tissue (gt), flanked by packages of hair follicles (arrowheads). D: High magnification on the asterisk region from C; thicker epidermis (e) with more than 10 nucleated cell layers and basal finger like projections (arrow); granulation tissue with abundant blood vessels (small arrowhead). E: Wound healing in zone treated with IIS (W/IIS). Epidermis (asterisk) free of hairs and only a small region of granulation tissue below (gt), flanked by profuse bundles of hair.follicles (arrowheads). F: High magnification on the asterisk region from E; thicker epidermis (e) with more than 5 nucleated cell layers and granulation tissue with abundant blood vessels (small arrowhead). G: Normal skin (NORMAL) with very thin epidermis (asterisk) and below the connective tissue (ct) in pale blue, traversed by hair follicles (thick white arrow). H: High magnification on the asterisk region from G; epidermis (e) with no more than 2 nucleated cell layers and abundant connective tissue with bundles of hair follicles. Scale bar: A, C, E, G = 2 mm; B, D, F, H = 100 μm.