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Table 2 Genes potentially regulated by modifications of histone acetylation in human CM

From: Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies

PATHWAY

GENE

SOURCE

HDACi

MODULATION BY HDACi

FUNCTION

REFERENCE

APOPTOSIS

BAKa

cell line

SBHAb

up-regulation

pro-apoptotic

[54, 106, 151]

 

BAX

cell line

SBHA, NaB

up-regulation

pro-apoptotic

[54, 56, 106, 151]

 

BCL-X

cell line

SAHA, SBHA, TSA

down-regulation

anti-apoptotic

[54, 106, 151, 152]

 

BID

cell line

SBHA

up-regulation

pro-apoptotic

[151]

 

BIM

cell line

SBHA

up-regulation

pro-apoptotic

[54, 106, 151]

 

CASP3

cell line

SBHA

up-regulation

pro-apoptotic

[151]

 

CASP8

cell line

SBHA

up-regulation

pro-apoptotic

[151]

 

MCL-1

cell line

SBHA

down-regulation

anti-apoptotic

[54, 106, 151]

 

TRAILR1

cell line

SAHA, TSA

up-regulation

pro-apoptotic

[152]

 

TRAILR2

cell line

TSA, SAHA

up-regulation

pro-apoptotic

[152]

 

XIAP

cell line

SBHA

down-regulation

anti-apoptotic

[54, 106, 151]

CELL CYCLE

CCNA

cell line

TSA

down-regulation

promotes cell cycle progression

[53]

 

CCND1

cell line

TSA, VPA

down-regulation

promotes cell cycle progression

[53, 114]

 

CCND3

cell line

TSA

up-regulation

promotes cell cycle progression

[53]

 

CCNE

cell line

TSA

up-regulation

promotes cell cycle progression

[53, 153]

 

CDKN1A

cell line

LAQ824, VPA, MS-275, NaB, TSA

up-regulation

inhibits cell cycle progression

[53, 110, 114, 154–157]

 

CDKN2A

cell line

VPA

up-regulation

inhibits cell cycle progression

[114]

 

TP53

cell line

TSA

down-regulation

inhibits cell cycle progression

[53]

DNA REPAIR

KU70

cell line

NaB, SAHA, TSA

down-regulation

repairing radiation-induced DNA damages

[119, 120]

 

KU80

cell line

SAHA

down-regulation

repairing radiation-induced DNA damages

[120]

 

KU86

cell line

NaB, TSA

down-regulation

repairing radiation-induced DNA damages

[119]

 

RAD50

cell line

SAHA

down-regulation

repairing radiation-induced DNA damages

[120]

INVASION/

METASTASIS

CCR7

cell line

TSA

up-regulation

promotes cell migration

[141]

 

CXCR4

cell line

TSA

up-regulation

promotes cell migration

[141]

 

MMP10

cell line

Apicidin

down-regulation

promotes invasion

[158]

 

MMP2

cell line

Apicidin

up-regulation

promotes invasion

[158]

SIGNALING

OSMR

cell line

TSA

up-regulation

anti-proliferative signals

[159]

 

RAP 1

cell line

FK228

up-regulation

inhibits RAS signaling

[160]

 

RARB

cell line

LAQ824

up-regulation

transduces RA signals

[110]

  1. a, gene symbol: BAK, BCL2-antagonist/killer; Bax, BCL2-associated X protein; Bid, BH3 interacting domain death agonist; BIM, bcl-2 interacting mediator of cell death; CASP3,caspase-3; CASP8, Caspase 8; CCNA, cyclin A; CCND1, cyclin D1; CCND3, cyclin D3; CCNE, cyclin E; CCNE, cyclin E; CDKN1A, cyclin-dependent kinase inhibitor 1A; LEF-1, lymphoid enhancer factor-1; MCL-1, myeloid cell leukemia sequence 1; MMP2, matrix metallopeptidase 2; MMP10, matrix metallopeptidase 10; OSMR, oncostatin M receptor beta; TP53, tumor protein p53; TRAILR2, TNF-related apoptosis inducing ligand receptor 2; XIAP, X-linked inhibitor of apoptosis.
  2. b, HDACi: NaB, sodium butyrate; SAHA, suberoylanilide hydroxamic acid; SBHA, suberic bishydroxamic acid; TSA, tricostatin A; VPA, valproic acid.