From: Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies
PATHWAY | GENE | SOURCE | HDACi | MODULATION BY HDACi | FUNCTION | REFERENCE |
---|---|---|---|---|---|---|
APOPTOSIS | BAKa | cell line | SBHAb | up-regulation | pro-apoptotic | |
 | BAX | cell line | SBHA, NaB | up-regulation | pro-apoptotic | |
 | BCL-X | cell line | SAHA, SBHA, TSA | down-regulation | anti-apoptotic | |
 | BID | cell line | SBHA | up-regulation | pro-apoptotic | [151] |
 | BIM | cell line | SBHA | up-regulation | pro-apoptotic | |
 | CASP3 | cell line | SBHA | up-regulation | pro-apoptotic | [151] |
 | CASP8 | cell line | SBHA | up-regulation | pro-apoptotic | [151] |
 | MCL-1 | cell line | SBHA | down-regulation | anti-apoptotic | |
 | TRAILR1 | cell line | SAHA, TSA | up-regulation | pro-apoptotic | [152] |
 | TRAILR2 | cell line | TSA, SAHA | up-regulation | pro-apoptotic | [152] |
 | XIAP | cell line | SBHA | down-regulation | anti-apoptotic | |
CELL CYCLE | CCNA | cell line | TSA | down-regulation | promotes cell cycle progression | [53] |
 | CCND1 | cell line | TSA, VPA | down-regulation | promotes cell cycle progression | |
 | CCND3 | cell line | TSA | up-regulation | promotes cell cycle progression | [53] |
 | CCNE | cell line | TSA | up-regulation | promotes cell cycle progression | |
 | CDKN1A | cell line | LAQ824, VPA, MS-275, NaB, TSA | up-regulation | inhibits cell cycle progression | |
 | CDKN2A | cell line | VPA | up-regulation | inhibits cell cycle progression | [114] |
 | TP53 | cell line | TSA | down-regulation | inhibits cell cycle progression | [53] |
DNA REPAIR | KU70 | cell line | NaB, SAHA, TSA | down-regulation | repairing radiation-induced DNA damages | |
 | KU80 | cell line | SAHA | down-regulation | repairing radiation-induced DNA damages | [120] |
 | KU86 | cell line | NaB, TSA | down-regulation | repairing radiation-induced DNA damages | [119] |
 | RAD50 | cell line | SAHA | down-regulation | repairing radiation-induced DNA damages | [120] |
INVASION/ METASTASIS | CCR7 | cell line | TSA | up-regulation | promotes cell migration | [141] |
 | CXCR4 | cell line | TSA | up-regulation | promotes cell migration | [141] |
 | MMP10 | cell line | Apicidin | down-regulation | promotes invasion | [158] |
 | MMP2 | cell line | Apicidin | up-regulation | promotes invasion | [158] |
SIGNALING | OSMR | cell line | TSA | up-regulation | anti-proliferative signals | [159] |
 | RAP 1 | cell line | FK228 | up-regulation | inhibits RAS signaling | [160] |
 | RARB | cell line | LAQ824 | up-regulation | transduces RA signals | [110] |