Figure 5
From: Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody
Gene expression levels in blood of cynomolgus monkeys before and after IV administration of Ab-01. Genes tested were selected based on known association with cytokine storm and/or reponsiveness of cynomolgus blood cells to ex vivo stimulation with rhIL21. Results from control untreated monkeys were comparable to Ab-01-treated monkeys. No signficant changes over pre-dose levels were observed, and no significant differences between control and treated monkeys were observed. Details of sampling by monkey is given in Additional file 2, Table S1.