Figure 1

RNA expression levels relative to negative control in IL21-responsive genes. Dry coated conditions. RNA expression in cells cultured under indicated conditions. Mean fold changes and 95% confidence limits with Ab-01 relative to IgG₁TM control (from 5 donors tested at concentrations less than 10 μg/well) are shown for genes where the absolute fold-change >1.5 and the 95% confidence limit excluded no change. For the IL21 tests, results are shown as average fold change relative to media control for all tests where the absolute fold-change >1.5 and the 95% confidence limit excluded no change. Confidence intervals were calculated in log-space and back-transformed and are represented by the error bars. Increases are shown in red, and decreases in green. The value 1 on the Y axis represents no change relative to control.