Toll-like receptor 9 polymorphisms influence mother-to-child transmission of human immunodeficiency virus type 1

Table 1 Frequencies of TLR9 genotypes and haplotypes and risk of HIV-1 infection.

SNP	Genotypes	Uninfected children (n = 182)	Infected children (n = 118)	OR	95% CI		p
					LCL	UCL
c.4-44G > A(rs352139)	GG	0.29	0.36	1			0.48
	GA	0.50	0.44	0.72	0.42	1.22
	AA	0.31	0.20	0.80	0.42	1.53
c.1635A > G(rs352140)	AA	0.31	0.39	1			0.20
	AG	0.48	0.38	0.62	0.37	1.06
	GG	0.21	0.23	0.86	0.46	1.62
Haplotypes	G;A	0.53	0.51	1
	A;G	0.44	0.36	0.92	0.65	1.30	0.63*
	A;A	0.02	0.07	3.16	1.24	8.03	0.016*
	G;G	0.01	0.06	5.54	1.76	17.50	0.0038*

LCL, lower confidence limit; UCL, upper confidence limit.
* The significance level after Bonferroni correction for multiple testing is 0.017 instead of 0.05.

ISSN: 1479-5876