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Table 4 Genes up- or down-regulated in IPC patients compared to control patients at 1 hour into surgery (t = 1)

From: Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients

Gene name Gene symbol Public ID Fold change P
Immediate early genes     
Early growth response 1 EGR1 AV733950 2.84 0.001
Myc proto oncogene protein MYC NM_002467 2.58 0.038
Cellular oncogene c-fos FOS BC004490 2.11 0.018
Immediate early response 2 IER2 NM_004907 1.58 0.034
Jun oncogene JUN BC002646 1.43 0.001
Oxidative stress defence     
Catalase CAT AU147084 2.14 0.017
Glutathione S-transferase theta 1 GSTT1 AL359937 2.69 0.025
Sequestosome 1 SQSTM1 AW293441 2.04 0.018
Chaperone/Survival     
DnaJ (Hsp40) homolog, subfamily B, member 6 DNAJB6 AF080569 1.45 0.042
Heat shock 22 kDa protein 8 HSPB8 BF109740 1.83 0.001
BCL2/adenovirus E1 B 19 kDa interacting protein 1 BNIP1 NM_013979 1.50 0.004
BCL6 co-repressor BCOR AF317391 1.74 0.047
Anti-apoptotic     
Caspase 8 CASP8 BF439983 -2.00 0.045
Caspase 7 CASP7 NM_001227 -1.31 0.026
Mitochondrial     
Uncoupling protein 3 UCP3 NM_003356 2.41 0.001
Pyruvate dehydrogenase kinase 4 PDK4 AL832708 2.99 0.009
  1. * A positive number indicates elevated expression (fold change) in skeletal muscle tissue of IPC-treated patient compared to skeletal muscle tissue of control patient. A negative number indicates decreased expression (fold change) in skeletal muscle tissue of IPC-treated patient compared to skeletal muscle tissue of control patient.