Figure 4
From: HSF1 overexpression enhances oncolytic effect of replicative adenovirus
HSF1 overexpression enhances the antitumoral efficacy of Adel55 in nude mice tumor model. Five-week-old female BALB/c nu/nu mice were injected subcutaneously and bilaterally with 106 Bcap37, Bcap37/LXSN, Bcap37/cHSF1 or Bcap37/HSF1i cells suspended in 200 μl of serum free DMEM. When tumor volumes reached about 30 mm3, mice were intratumorally injected with PBS or 5×108 PFU of Adel55 once a day for 2 consecutive days. The tumor volume was measured at 5-day intervals and is presented as means ± SD of eight mice.