Non-monotonic changes in clonogenic cell survival induced by disulphonated aluminum phthalocyanine photodynamic treatment in a human glioma cell line

Table 1 Testing of overall differences of mean relative proliferation among different treatment groups as well as at each pre-specified time by using one-way Analysis of Variance (one-way ANOVA) with Bonferroni correction for pairwise group comparisons.

	Pairwise Comparison	Mean Difference (Estimate [Standard Error])	P-value**
Overall			0.0001*
	1 μM vs. control	-0.8192 (0.4673)	0.0923
	5 μM vs. control	-2.6097 (0.4673)	0.0001
	5 μM vs. 1 μM	-1.7904 (0.4673)	0.0008
19 h			0.0001*
	1 μM vs. control	-0.3503 (0.3322)	0.3323
	5 μM vs. control	-1.1040 (0.3322)	0.0159
	5 μM vs. 1 μM	-0.7537 (0.3322)	0.0638
30 h			0.0001*
	1 μM vs. control	-1.183 (0.1116)	0.0001
	5 μM vs. control	-2.8440 (0.1116)	0.0001
	5 μM vs. 1 μM	-1.6610 (0.1116)	0.0001
42 h			0.0001*
	1 μM vs. control	-0.9243 (0.3034)	0.0226
	5 μM vs. control	-3.8810 (0.3034)	0.0001
	5 μM vs. 1 μM	-2.9567 (0.3034)	0.0001

* overall group differences calculated by F-test from one-way ANOVA
** all the p-values noted as "*" should be compared with 5% and all others with 1.66% due to pairwise comparisons with Bonferroni correction.

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