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Table 2 Relative quantification (RQ) of gene expression induced by ex vivo addition of rhuIL-21 to whole blood obtained from male cynomolgus monkeys

From: Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys

ANIMAL #

IL-2RA

IL-21R

PRF1

GZMB

IL-6

1

2.8

2.5

2.8

2.0

4.2

2

3.4

2.3

1.2

1.1

1.7

3

5.5

2.9

2.5

1.4

3.6

4

4.1

2.1

2.5

1.1

4.9

5

5.3

3.2

2.1

2.1

4.1

6

2.8

1.8

1.8

2.0

0.5

7

6.3

1.9

2.4

1.9

2.6

8

2.8

1.8

1.6

1.6

6.7

9

3.8

2.0

1.9

2.2

1.2

10

2.9

1.8

0.7

1.0

0.9

11

7.7

3.4

2.6

2.2

2.8

12

4.5

3.6

1.4

1.5

1.1

13

2.1

1.5

1.1

1.2

1.4