Figure 2

Serum concentrations following a single 10 mg/kg IV dosage of anti-IL-21R antibody Ab-01 or Ab-02 to cynomolgus monkeys. Serum samples were collected up to 148 days for Ab-01 (filled symbols and solid lines) and up to 36 days for Ab-02 (open symbols and dashed lines) post-dose. Ab-01 and Ab-02 serum concentrations were measured by a specific ELISA, in which his-tagged rhuIL-21 and an anti-human Fc antibody were used as a capture and a detector, respectively. Data points with serum concentrations below the LOQ of 30 ng/mL (after day 71 and day 15 for Ab-01 and Ab-02, respectively), are not shown. an = animal number.