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Figure 1 | Journal of Translational Medicine

Figure 1

From: Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits

Figure 1

Prime-boost protocols for rabbit immunisation. Animals were immunised i.d. every month and bled before each inoculation. Four immunisation protocols were applied. In Protocol 1, the animals were immunised with the FPE6 recombinant (108 PFU/animal), in Protocol 2 with the FPE7 recombinant (108 PFU/animal), in Protocol 3 with the FPE6 + FPE7 recombinants (108 PFU/recombinant/animal), in Protocol 4 with FPwt (108 PFU/animal). In Protocols 2 and 3 the animals were also boosted with the recombinant E7 protein (100 μg/boost). Rabbits # 50, 62 and 83 died for natural reasons before the fifth priming. T1-T5, immunisation times for priming; P1-P4, immunisation times for protein boost.

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