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Table 4 Genes down-regulated during DC maturation that could be used as biomarkers for assessing mDCs

From: Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies

 

Fold decrease in gene expression for each maturation time*

Gene

4 hours

8 hours

24 hours

Genes down-regulated to a similar degree throughout maturation

CD1C

64.0

82.2

57.8

MYC

9.17

8.83

9.35

MAF

15.0

8.30

20.5

PTGS1

5.43

20.4

13.0

DOK2

8.78

7.03

9.63

Genes down-regulated most late in DC maturation

TGFBI

2.44

6.76

11.2

GATM

2.70

12.0

17.7

ARHGDIB

2.37

10.1

15.4

MRC1

NS

7.15

30.22

CLEC10A

3.82

28.2

43.5

  1. Fold-increase compared to iDCs.