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Table 3 Genes up-regulated during DC maturation that could be used as biomarkers for assessing mDCs

From: Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies

 

Fold increase in gene expression for each maturation time*

Gene

4 hours

8 hours

24 hours

Gene

4 hours

8 hours

24 hours

Up-regulated to a similar degree throughout maturation

Up-regulated most early in DC maturation

aCCL5

108

148

94.1

IL6

13.1

11.3

5.15

CXCL10

28.5

31.8

21.2

IL8

78.0

70.3

12.7

CCR7

10.5

11.5

18.2

IL7R

29.1

29.9

10.5

IL15

7.12

5.54

8.13

CCL4

92.3

53.4

6.91

IFI27

6.99

7.62

10.2

TNFAIP6

30.0

18.7

10.7

IFI44L

14.8

16.7

20.5

IFIT3

36.2

22.5

10.5

IFIH1

16.9

9.42

11.3

OASL

68.1

44.1

30.7

IFIT1

29.8

27.0

21.7

GBP1

66.2

35.3

30.2

MX1

18.4

15.6

14.1

HES4

229

115

37.4

ISG15

50.6

58.3

41.8

Up-regulated most late in DC maturation

ISG20

94.1

87.9

62.9

CCL8

11.3

31.8

31.2

IRF7

9.77

9.38

12.0

EBI3

17.6

21.8

34.6

GBP4

36.3

21.2

20.2

IFITM1

13.2

22.5

48.6

DUSP5

21.7

15.8

22.6

MT1B

10.2

10.5

20.6

NFKBIA

11.7

13.3

10.4

MT1E

NS

1.78

46.1

ATF3

10.2

5.38

11.4

MT1G

NS

2.77

42.3

TNFSF10

19.4

14.8

13.8

MT1H

22.7

20.5

62.6

TNFRSF9

8.13

6.39

10.2

GADD45A

NS

11.6

50.7

SOD2

51.6

58.4

28.0

CD200

2.49

4.94

15.1

CD38

8.35

9.26

9.02

LAMP3

11.7

17.5

37.4

CD44

3.48

1.76

2.18

RGS1

5.70

18.1

28.3

CD80

3.14

2.93

3.49

SAT1

3.79

6.26

18.1

CD83

22.0

17.3

23.6

CYP27B1

6.59

12.5

21.4

CD86

1.62

1.32

2.34

RIPK2

10.7

14.0

23.1

INDO

28.6

18.6

16.3

    

MT2A

54.3

72.0

69.2

    

TRAF1

31.4

16.7

24.4

    

GADD45B

17.8

10.7

10.2

    

MT1M

8.26

8.40

15.1

    

MT1P2

14.6

13.9

20.3

    

BIRC3

23.0

18.4

28.2

    

USP18

34.7

29.9

29.8

    

TUBB2A

10.7

8.19

10.4

    
  1. Fold-increase compared to iDCs.