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Table 3 Genes up-regulated during DC maturation that could be used as biomarkers for assessing mDCs

From: Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies

  Fold increase in gene expression for each maturation time*
Gene 4 hours 8 hours 24 hours Gene 4 hours 8 hours 24 hours
Up-regulated to a similar degree throughout maturation Up-regulated most early in DC maturation
aCCL5 108 148 94.1 IL6 13.1 11.3 5.15
CXCL10 28.5 31.8 21.2 IL8 78.0 70.3 12.7
CCR7 10.5 11.5 18.2 IL7R 29.1 29.9 10.5
IL15 7.12 5.54 8.13 CCL4 92.3 53.4 6.91
IFI27 6.99 7.62 10.2 TNFAIP6 30.0 18.7 10.7
IFI44L 14.8 16.7 20.5 IFIT3 36.2 22.5 10.5
IFIH1 16.9 9.42 11.3 OASL 68.1 44.1 30.7
IFIT1 29.8 27.0 21.7 GBP1 66.2 35.3 30.2
MX1 18.4 15.6 14.1 HES4 229 115 37.4
ISG15 50.6 58.3 41.8 Up-regulated most late in DC maturation
ISG20 94.1 87.9 62.9 CCL8 11.3 31.8 31.2
IRF7 9.77 9.38 12.0 EBI3 17.6 21.8 34.6
GBP4 36.3 21.2 20.2 IFITM1 13.2 22.5 48.6
DUSP5 21.7 15.8 22.6 MT1B 10.2 10.5 20.6
NFKBIA 11.7 13.3 10.4 MT1E NS 1.78 46.1
ATF3 10.2 5.38 11.4 MT1G NS 2.77 42.3
TNFSF10 19.4 14.8 13.8 MT1H 22.7 20.5 62.6
TNFRSF9 8.13 6.39 10.2 GADD45A NS 11.6 50.7
SOD2 51.6 58.4 28.0 CD200 2.49 4.94 15.1
CD38 8.35 9.26 9.02 LAMP3 11.7 17.5 37.4
CD44 3.48 1.76 2.18 RGS1 5.70 18.1 28.3
CD80 3.14 2.93 3.49 SAT1 3.79 6.26 18.1
CD83 22.0 17.3 23.6 CYP27B1 6.59 12.5 21.4
CD86 1.62 1.32 2.34 RIPK2 10.7 14.0 23.1
INDO 28.6 18.6 16.3     
MT2A 54.3 72.0 69.2     
TRAF1 31.4 16.7 24.4     
GADD45B 17.8 10.7 10.2     
MT1M 8.26 8.40 15.1     
MT1P2 14.6 13.9 20.3     
BIRC3 23.0 18.4 28.2     
USP18 34.7 29.9 29.8     
TUBB2A 10.7 8.19 10.4     
  1. Fold-increase compared to iDCs.