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Table 1 Condensed data on patients histories and sample type

From: "Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression"

Gender

Age

Underlying

disease

Year of

Tx.

Kidney explant

or

biopsy

Why

indicated ?

Histo-

pathological

diagnosis

Tissue

samples

analyzed

n =

Symbol#in Figure8

female

60

Systemic Lupus erythematosus

1999*

Kidney

explant

(01/2007)

Acute

renal failure

(Interstitial fibrosis, tubular atrophy)

Banff 2007,

5. II [34]

2

Black circle

Black

square

female

41

Systemic vasculitis (Purpura Schoenlein-Henoch)

1996

Kidney

explant

(01/2007)

Acute

renal failure

(Interstitial fibrosis, tubular atrophy)

Banff 2007,

5. II [34]

1

Black

triangle

male

17

Obstructive

uropathy

2006*

Kidney

explant

(08/2007)

Impaired

kidney

function

(Interstitial fibrosis, tubular atrophy)

Banff 2007,

5. III [34]

2

Black

reverse

triangle

Black

rhomb

female

45

Chronic glomerulo-nephritis

1996

Indication

biopsy

(04/2007)

Impaired

kidney

function

Chronic tubulo-interstitial injury,

evidence for calcineurin

inhibitor

toxicity (CNIT)

1

White

circle

male

72

Chronic interstitial nephritis

2007

Indication

biopsy

(06/2007)

Impaired

kidney

function

Interstitial fibrosis, tubular atrophy, vasculopathy)

Banff 2007,

5. II [34] **

1

White

square

female

42

Systemic Lupus erythematosus

2005

Kidney

explant

(2005)

Allograft-steal-syndrome

Diffuse tubular

damage

2

Black

circles

in plot "Control"

Not known

(anonymized)

RCC

n.a.

Tumor

nephrectomy

RCC

Normal

1

 
  

RCC

  

RCC

 

1

 
  

RCC

  

RCC

 

1

 
  1. 2nd allograft in patients history, ** = "old-for-old" kidney allocation, Tx. = transplantation, RCC = renal cell carcinoma, n.a. = not attributable. #Two symbols per case mean that 2 different tissue blocks were analyzed in the same patient.