Increased expression of SERPINE1 mRNA (A) and down-regulation of miRNA-449a/b (B + C) in human kidney transplants. All cases showed an inverse mode of expression. Symbols represent the mean of 3 independent quantitative analyses of tissue blocks or biopsies as indicated in Table 1. The mean expression of SERPINE1 and miRNA-449a/b in the control kidney samples was arbitrarily set to 1. * = p < 0.05; ** = p < 0.01; *** = p < 0.001.