Gene expression profiling in fibroblasts under hypoxia. Primary human fibroblasts were analysed by LDA designed to determine fibrosis- and ECM-related gene expression. Depicted are the mean and range of gene expression in fibroblasts under hypoxia relative to reference gene POLR2A. Shown are results from cell line F-18. Among other factors induced in the hypoxic culture SERPINE1 mRNA was increased 10-fold. *** = p < 0.001, ** = p < 0.01 (two independent experiments).