Figure 1

MiRNA profiling and identification of candidates in fibroblasts under hypoxia. MiRNA profiling of a total of 377 different miRNA species revealed down-regulation of miRNA-449a, -449b and -518a-3p when primary fibroblasts were cultured under hypoxic conditions (relative to RNU48). Shown are results from cell line F-18. *** = p < 0.001, ** = p < 0.01 (two independent experiments).