Figure 2

The Mean Log [relative Liver HBV DNA (PCR)] by treatment group and gender for HBV mice. DCP was administered per os, once daily for 14 days to 94 randomly assigned HBV transgenic mice at 23 mg/(kg d) (10 females/10 males), 7.3 mg/(kg d) (10 females/10 males), and 2.3 mg/(kg d) (10 females/10 males). ADV was used as a positive control at 10 mg/(kg d) (10 females/5 males) using the same treatment schedule and vehicle (0.4% CMC). 10 female/9 male control vehicle mice were used. Mean Log [relative Liver HBV DNA (PCR)] values, as measured by quantitative PCR are graphed by treatment group and gender for HBV mice (ADV = Adefovir dipivoxil). * (p < .05) - Mean Log [relative liver HBV DNA (PCR)] is significantly different than controls [DCP = 0.0 mg/(kg d) of the same gender] for females at 23.0 mg/(kg d) DCP and for ADV in both females and males. ^#### (p ≤ .001) - Mean Log [relative liver HBV DNA (PCR)] is significantly different by gender.