Epstein-Barr virus encoded latent membrane protein 1 regulates mTOR signaling pathway genes which predict poor prognosis of nasopharyngeal carcinoma

Table 2 Univariate and multivariate analysis of Cox proportional hazards model in NPC.

Characristics	Hazard ratio	95% CI	P-value
Univariate analysis
Gender (male vs. female)	0.422	0.232-0.770	0.005*
Age (< 46 vs. ≥ 46)	1.721	1.085-2.729	0.021*
WHO type (I vs. IV)	1.025	0.618-1.700	0.925
Clinical stage (I + II vs. III + IV)	1.824	1.012-3.286	0.045*
T stage (T1~2 vs. T3~4)	1.571	0.972-2.540	0.065
N stage (N0 vs. N1~3)	0.936	0.568-1.544	0.796
Recurrence (no vs. yes)	1.442	0.895-2.322	0.132
Metastasis (no vs. yes)	2.466	1.412-4.304	0.002*
LMP1 expression (low vs. high)	1.863	1.091-3.183	0.023*
p-mTOR expression (low vs. high)	1.274	0.796-2.040	0.314
p-P70S6K expression (low vs. high)	1.447	0.907-2.309	0.121
p-4EBP1 expression (low vs. high)	1.920	1.154-3.195	0.012*
Multivariate analysis
Gender (male vs. female)	0.447	0.234-0.851	0.014*
Metastasis (no vs. yes)	2.591	1.383-4.856	0.003*
LMP1 expression (low vs. high)	2.056	1.161-3.641	0.013*

ISSN: 1479-5876