Microrna profiling analysis of differences between the melanoma of young adults and older adults

Table 8 MiRs Significantly Differentially Expressed Between Stage I-II Adult Melanoma (Mel 60) And Stage I-II Young Adult-Pediatric Melanoma (Mel 30)

MiR	Parametric p-value	FDR	Permutation p-value	Geom mean of intensities in class 1	Geom mean of intensities in class 2	Fold-change
hsa-miR-30aSTAR-4373062	0.0001	0.0733	0.0022	7.7570	6.1934	1.2525
hsa-miR-30eSTAR-4373057	0.0003	0.1046	0.0022	6.8663	5.7540	1.1933
hsa-miR-10bSTAR-4395426	0.0007	0.1507	0.0022	10.5589	9.4540	1.1169
hsa-miR-337-5p-4395267	0.0009	0.1524	0.0022	17.2304	14.8781	1.1581

Stage I-II Adult melanoma were compared with stage I-II pediatric melanoma by Two-sample T-test on the global data set of 666 miRs C_T values normalized to MammU6 endogenous control (see analysis II). Class 1: Mel 30 Stage I-II; Class 2: Mel 60 Stage I-II. Exact permutation p-values for significant genes were computed based on 462 available permutations. Nominal significance level of each univariate test: 0.001. Global test: probability of getting at least 4 genes significant by chance (at the 0.001 level) if there are no real differences between the classes: 0.02597.

ISSN: 1479-5876