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Table 4 Mirs Significantly Differentially Expressed Between Adult Nevus (Nevus 60) And Adult Melanoma (Mel 60)

From: Microrna profiling analysis of differences between the melanoma of young adults and older adults

Array A Hsa-miR Name-Assay# FC (NEVUS60/MEL60) Log2(FC) p value FDR (BH) FC Bin
hsa-miR-211-4373088 23.2024 4.5362 0.0000 0.0009 FC > 4
hsa-miR-455-5p-4378098 4.0390 2.0140 0.0001 0.0099 FC > 4
hsa-miR-891a-4395302 11.9232 3.5757 0.0010 0.0768 FC > 4
hsa-miR-532-3p-4395466 2.0532 1.0379 0.0017 0.0997 FC 2.0-4.0
hsa-miR-888-4395323 9.6379 3.2687 0.0023 0.1103 FC > 4
hsa-miR-574-3p-4395460 1.7254 0.7869 0.0037 0.1287 FC 1.6-2.0
hsa-miR-510-4395352 11.7097 3.5496 0.0038 0.1287 FC > 4
hsa-miR-382-4373019 0.0794 -3.6541 0.0049 0.1454 FC > 4
hsa-miR-98-4373009 0.0532 -4.2327 0.0099 0.2571 FC > 4
hsa-miR-576-3p-4395462 0.2275 -2.1362 0.0109 0.2571 FC > 4
hsa-miR-539-4378103 0.2609 -1.9384 0.0118 0.2571 FC 2.0-4.0
hsa-miR-509-5p-4395346 5.3581 2.4217 0.0173 0.3251 FC > 4
hsa-miR-424-4373201 0.2554 -1.9691 0.0177 0.3251 FC 2.0-4.0
hsa-miR-513-5p-4395201 3.7696 1.9144 0.0208 0.3553 FC 2.0-4.0
hsa-miR-493-4395475 0.1723 -2.5369 0.0270 0.4147 FC > 4
hsa-miR-197-4373102 2.5425 1.3462 0.0290 0.4147 FC 2.0-4.0
hsa-miR-508-3p-4373233 3.3230 1.7325 0.0295 0.4147 FC 2.0-4.0
hsa-miR-146b-5p-4373178 0.3392 -1.5599 0.0382 0.5068 FC 2.0-4.0
hsa-miR-23b-4373073 3.4283 1.7775 0.0414 0.5208 FC 2.0-4.0
hsa-miR-362-5p-4378092 0.5702 -0.8104 0.0442 0.5208 FC 1.6-2.0
hsa-miR-223-4395406 0.3426 -1.5453 0.0458 0.5208 FC 2.0-4.0
Array B Hsa-miR Name-Assay# FC (NEVUS60/MEL60) Log2(FC) p value FDR (BH) FC Bin
hsa-miR-7-4378130 0.3368 -1.5701 0.0014 0.1379 FC 2.0-4.0
hsa-miR-223STAR-4395209 0.0939 -3.4130 0.0045 0.1753 FC > 4
hsa-miR-566-4380943 8.3006 3.0532 0.0054 0.1753 FC > 4
hsa-miR-409-3p-4395443 0.1789 -2.4824 0.0160 0.2391 FC > 4
hsa-miR-632-4380977 1.7186 0.7812 0.0168 0.2391 FC 1.6-2.0
hsa-miR-650-4381006 0.1692 -2.5635 0.0173 0.2391 FC > 4
hsa-miR-181a-2STAR-4395428 1.7991 0.8473 0.0225 0.2391 FC 1.6-2.0
hsa-miR-432-4373280 0.0997 -3.3257 0.0233 0.2391 FC > 4
hsa-miR-571-4381016 0.3030 -1.7224 0.0237 0.2391 FC 2.0-4.0
hsa-miR-193bSTAR-4395477 3.7280 1.8984 0.0281 0.2391 FC 2.0-4.0
hsa-miR-604-4380973 0.4573 -1.1288 0.0288 0.2391 FC 2.0-4.0
hsa-miR-513-3p-4395202 3.2062 1.6809 0.0293 0.2391 FC 2.0-4.0
hsa-miR-22STAR-4395412 0.1556 -2.6844 0.0347 0.2495 FC > 4
hsa-miR-801-4395183 0.1982 -2.3350 0.0356 0.2495 FC > 4
hsa-miR-20aSTAR-4395548 2.5320 1.3403 0.0465 0.3040 FC 2.0-4.0
  1. Array A: TLDA panel A (377 functionally defined microRNAs) array B: TLDA panel B (290 MicroRNAs whose function is not yet completely defined) TLDA A and B totaled 667 microRNA assays. FC: fold change; Pvalue student T test ≤ 0.05; FDR: false discovery rate; FC bin: Range of fold change. MirRs in bold font were found to be significantly differentially expressed between the two groups by the relative quantification (ABqPCR software-Analysis I) based method and by Class Comparison (BRB tools-Analysis II) based on absolute CT values normalized to endogenous control MammU6 (see materials and methods). N/A: not applicable.