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Table 4 Mirs Significantly Differentially Expressed Between Adult Nevus (Nevus 60) And Adult Melanoma (Mel 60)

From: Microrna profiling analysis of differences between the melanoma of young adults and older adults

Array A Hsa-miR Name-Assay#

FC (NEVUS60/MEL60)

Log2(FC)

p value

FDR (BH)

FC Bin

hsa-miR-211-4373088

23.2024

4.5362

0.0000

0.0009

FC > 4

hsa-miR-455-5p-4378098

4.0390

2.0140

0.0001

0.0099

FC > 4

hsa-miR-891a-4395302

11.9232

3.5757

0.0010

0.0768

FC > 4

hsa-miR-532-3p-4395466

2.0532

1.0379

0.0017

0.0997

FC 2.0-4.0

hsa-miR-888-4395323

9.6379

3.2687

0.0023

0.1103

FC > 4

hsa-miR-574-3p-4395460

1.7254

0.7869

0.0037

0.1287

FC 1.6-2.0

hsa-miR-510-4395352

11.7097

3.5496

0.0038

0.1287

FC > 4

hsa-miR-382-4373019

0.0794

-3.6541

0.0049

0.1454

FC > 4

hsa-miR-98-4373009

0.0532

-4.2327

0.0099

0.2571

FC > 4

hsa-miR-576-3p-4395462

0.2275

-2.1362

0.0109

0.2571

FC > 4

hsa-miR-539-4378103

0.2609

-1.9384

0.0118

0.2571

FC 2.0-4.0

hsa-miR-509-5p-4395346

5.3581

2.4217

0.0173

0.3251

FC > 4

hsa-miR-424-4373201

0.2554

-1.9691

0.0177

0.3251

FC 2.0-4.0

hsa-miR-513-5p-4395201

3.7696

1.9144

0.0208

0.3553

FC 2.0-4.0

hsa-miR-493-4395475

0.1723

-2.5369

0.0270

0.4147

FC > 4

hsa-miR-197-4373102

2.5425

1.3462

0.0290

0.4147

FC 2.0-4.0

hsa-miR-508-3p-4373233

3.3230

1.7325

0.0295

0.4147

FC 2.0-4.0

hsa-miR-146b-5p-4373178

0.3392

-1.5599

0.0382

0.5068

FC 2.0-4.0

hsa-miR-23b-4373073

3.4283

1.7775

0.0414

0.5208

FC 2.0-4.0

hsa-miR-362-5p-4378092

0.5702

-0.8104

0.0442

0.5208

FC 1.6-2.0

hsa-miR-223-4395406

0.3426

-1.5453

0.0458

0.5208

FC 2.0-4.0

Array B Hsa-miR Name-Assay#

FC (NEVUS60/MEL60)

Log2(FC)

p value

FDR (BH)

FC Bin

hsa-miR-7-4378130

0.3368

-1.5701

0.0014

0.1379

FC 2.0-4.0

hsa-miR-223STAR-4395209

0.0939

-3.4130

0.0045

0.1753

FC > 4

hsa-miR-566-4380943

8.3006

3.0532

0.0054

0.1753

FC > 4

hsa-miR-409-3p-4395443

0.1789

-2.4824

0.0160

0.2391

FC > 4

hsa-miR-632-4380977

1.7186

0.7812

0.0168

0.2391

FC 1.6-2.0

hsa-miR-650-4381006

0.1692

-2.5635

0.0173

0.2391

FC > 4

hsa-miR-181a-2STAR-4395428

1.7991

0.8473

0.0225

0.2391

FC 1.6-2.0

hsa-miR-432-4373280

0.0997

-3.3257

0.0233

0.2391

FC > 4

hsa-miR-571-4381016

0.3030

-1.7224

0.0237

0.2391

FC 2.0-4.0

hsa-miR-193bSTAR-4395477

3.7280

1.8984

0.0281

0.2391

FC 2.0-4.0

hsa-miR-604-4380973

0.4573

-1.1288

0.0288

0.2391

FC 2.0-4.0

hsa-miR-513-3p-4395202

3.2062

1.6809

0.0293

0.2391

FC 2.0-4.0

hsa-miR-22STAR-4395412

0.1556

-2.6844

0.0347

0.2495

FC > 4

hsa-miR-801-4395183

0.1982

-2.3350

0.0356

0.2495

FC > 4

hsa-miR-20aSTAR-4395548

2.5320

1.3403

0.0465

0.3040

FC 2.0-4.0

  1. Array A: TLDA panel A (377 functionally defined microRNAs) array B: TLDA panel B (290 MicroRNAs whose function is not yet completely defined) TLDA A and B totaled 667 microRNA assays. FC: fold change; Pvalue student T test ≤ 0.05; FDR: false discovery rate; FC bin: Range of fold change. MirRs in bold font were found to be significantly differentially expressed between the two groups by the relative quantification (ABqPCR software-Analysis I) based method and by Class Comparison (BRB tools-Analysis II) based on absolute CT values normalized to endogenous control MammU6 (see materials and methods). N/A: not applicable.
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Journal of Translational Medicine

ISSN: 1479-5876

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