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Table 3 Mirs Significantly Differentially Expressed Between Older Adult Melanoma (Mel 60) And Pediatric And Young Adult Melanoma (Mel 30)

From: Microrna profiling analysis of differences between the melanoma of young adults and older adults

Array A Hsa-miR Name-Assay#

FC (MEL60/MEL30)

Log2(FC)

p value

FDR (BH)

FC Bin

hsa-miR-204-4373094

34.6805

5.1161

0.0007

0.1571

FC > 4

hsa-miR-199a-5p-4373272

4.3354

2.1162

0.0024

0.2701

FC > 4

hsa-miR-211-4373088

0.2785

-1.8441

0.0044

0.2701

FC 2.0-4.0

hsa-miR-574-3p-4395460

1.8143

0.8594

0.0053

0.2701

FC 1.6-2.0

hsa-miR-449a-4373207

0.3750

-1.4150

0.0057

0.2701

FC 2.0-4.0

hsa-miR-455-5p-4378098

0.4594

-1.1221

0.0070

0.2788

FC 2.0-4.0

hsa-miR-337-5p-4395267

2.6855

1.4252

0.0167

0.4867

FC 2.0-4.0

hsa-let-7b-4395446

1.9118

0.9349

0.0212

0.4867

FC 1.6-2.0

hsa-miR-140-3p-4395345

1.6343

0.7087

0.0221

0.4867

FC 1.6-2.0

hsa-miR-330-3p-4373047

1.9706

0.9786

0.0229

0.4867

FC 1.6-2.0

hsa-miR-489-4395469

1.8103

0.8563

0.0251

0.4867

FC 1.6-2.0

hsa-miR-24-4373072

0.6601

-0.5992

0.0264

0.4867

FC 1.2-1.6

hsa-miR-146b-3p-4395472

2.6336

1.3970

0.0283

0.4867

FC 2.0-4.0

hsa-miR-125b-4373148

1.8045

0.8516

0.0292

0.4867

FC 1.6-2.0

hsa-miR-192-4373108

0.6908

-0.5336

0.0334

0.4867

FC 1.2-1.6

hsa-miR-10b-4395329

2.2070

1.1421

0.0341

0.4867

FC 2.0-4.0

hsa-miR-199b-5p-4373100

2.3762

1.2486

0.0348

0.4867

FC 2.0-4.0

hsa-miR-19b-4373098

0.5745

-0.7996

0.0369

0.4873

FC 1.6-2.0

hsa-miR-423-5p-4395451

2.0952

1.0671

0.0398

0.4909

FC 2.0-4.0

hsa-miR-20a-4373286

0.5834

-0.7775

0.0421

0.4909

FC 1.6-2.0

hsa-miR-9-4373285

3.4546

1.7885

0.0433

0.4909

FC 2.0-4.0

Array B Hsa-miR Name-Assay#

FC (MEL60/MEL30)

Log2(FC)

p value

FDR (BH)

FC Bin

hsa-miR-30aSTAR-4373062

2.2183

1.1494

0.0000

0.0021

FC 2.0-4.0

hsa-miR-10bSTAR-4395426

1.7444

0.8027

0.0022

0.0739

FC 1.6-2.0

hsa-miR-30eSTAR-4373057

1.6826

0.7507

0.0026

0.0739

FC 1.6-2.0

hsa-miR-409-3p-4395443

2.1484

1.1032

0.0049

0.1038

FC 2.0-4.0

hsa-miR-29cSTAR-4381131

2.2418

1.1647

0.0069

0.1151

FC 2.0-4.0

hsa-miR-125b-1STAR-4395489

2.7217

1.4445

0.0096

0.1341

FC 2.0-4.0

hsa-miR-432-4373280

2.6512

1.4066

0.0157

0.1808

FC 2.0-4.0

hsa-miR-505STAR-4395198

2.2251

1.1539

0.0193

0.1808

FC 2.0-4.0

hsa-miR-944-4395300

0.4042

-1.3068

0.0204

0.1808

FC 2.0-4.0

hsa-miR-766-4395177

2.6347

1.3976

0.0215

0.1808

FC 2.0-4.0

hsa-miR-214STAR-4395404

1.7814

0.8330

0.0252

0.1926

FC 1.6-2.0

hsa-miR-99bSTAR-4395307

1.4101

0.4958

0.0285

0.1993

FC 1.2-1.6

hsa-miR-572-4381017

0.4892

-1.0314

0.0411

0.2653

FC 2.0-4.0

hsa-miR-768-3p-4395188

1.2722

0.3474

0.0483

0.2896

FC 1.2-1.6

  1. Array A: TLDA panel A (377 functionally defined microRNAs) array B: TLDA panel B (290 MicroRNAs whose function is not yet completely defined) TLDA A and B totaled 667 microRNA assays. FC: fold change; Pvalue student T test ≤ 0.05; FDR: false discovery rate; FC bin: Range of fold change. MirRs in bold font were found to be significantly differentially expressed between the two groups by the relative quantification (ABqPCR software-Analysis I) based method and by Class Comparison (BRB tools-Analysis II) based on absolute CT values normalized to endogenous control MammU6 (see materials and methods). N/A: not applicable.
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Journal of Translational Medicine

ISSN: 1479-5876

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