Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction

Table 1 Mean vascular density in the infarct zone of NOD/SCID β2m null mice with AMI four weeks post transplant of PBS, ALDH^lo Lin^- or ALDH^hi Lin^- sorted human UCB cells

Treatment^a	n^b	Mean vascular density/1000 μm^c	95% Confidence interval	p versus PBS
PBS	12	4.1	[3.3-5.0]	-
ALDH^loLin^-	5	5.4	[4.4-6.5]	0.279 (0.031)^d
ALDH^hiLin^-	9	6.0	[5.0-7.0]	0.011 (0.001)^d

^a NOD/SCID β2m null mice with AMI were transplanted with ALDH^loLin^- or ALDH^hiLin^- sorted human UCB cells or PBS. Frozen sections were stained with a mouse specific CD31 antibody and visualized with DAB+ chromagen.
^b Number of hearts analyzed pr. group; 10 randomly selected visual fields (40× magnification) in the tissue sub-served by the infarct related artery were analyzed from each heart.
^c CD31 positive vascular structures with a well defined tubular morphology or an open lumen or structures with a linear extension equal to or larger than 50 μm were included.
^d p-value after correction for outliers.

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