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Table 1 Multivariate Cox regression analyses of TTT.

From: Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells

 

HR (95% CI)*

p value

Model 1 (ISO-method)

  

β2M (>2.2 g/L)

3.48 (1.73-7.03)

5.1 × 10-4

Rai stages (II-III-IV)

5.76 (3.56-9.33)

<1 × 10-4

FISH (+12,11q-,17p-)

1.76 (1.34-2.31)

5.6 × 10-5

ZAP-70 (≥ 11%)

2.11 (1.24-3.57)

5.7 × 10-3

Model 2 (T-method)

  

β2M (>2.2 g/L)

3.16 (1.58-6.33)

1.2 × 10-3

Rai stages (II-III-IV)

5.97 (3.69-9.68)

<1 × 10-4

FISH (+12,11q-,17p-)

1.65 (1.26-2.17)

2.7 × 10-4

ZAP-70 (≥ 20%)

2.19 (1.29-3.72)

3.5 × 10-3

Model 3 (T/B Ratio-method)

  

β2M (>2.2 g/L)

3.11 (1.55-6.23)

1.5 × 10-3

Rai stages (II-III-IV)

5.95 (3.65-9.71)

<1 × 10-4

FISH (+12,11q-,17p-)

1.64 (1.25-2.15)

4.1 × 10-4

ZAP-70 (<3.0)

2.72 (1.56-4.75)

4.5 × 10-4

  1. Multivariate Cox regression analyses of TTT were performed on the 173 cases of the test set including the following covariates treated as dichotomous: β2-microglobulin (>2.2 g/L vs. ≤2.2 g/L); modified Rai staging (0-I vs. II-III-IV); FISH group (normal/13q- vs. +12/11q-/17p-); CD38 (≥ 30% vs. <30%); CD49d (≥ 30% vs. <30%); IGHV mutational status (UM vs. M); and ZAP-70.
  2. *Based on the final model after backward selection of covariates.
  3. Abbreviations: TTT, Time-To-first-Treatment; HR, hazard ratio; CI, confidence interval.
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Journal of Translational Medicine

ISSN: 1479-5876

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