Figure 4

ZAP-70 expression in the validation set. (A-B) Kaplan-Meier curves obtained comparing TTT of patients affected by CLL expressing ZAP-70 according to T-method (A) or T/B Ratio-method (B). In all plots solid line indicates ZAP-70 negative CLL, while dashed line indicates ZAP-70 positive CLL. (C) Venn diagram depicting concordant and discordant cases, as obtained by merging the ZAP-70 positive cases determined by the two readouts. (D) Kaplan-Meyer curves obtained comparing TTT of patients affected by CLL expressing ZAP-70 according to T/B Ratio-method (127 cases), expressing ZAP-70 according to sole T-method (58 cases), or ZAP-70 negative according to both methods (156 cases).