Morphologic complexity of epithelial architecture for predicting invasive breast cancer survival

Table 4 Summary of Split Sample Training Set and Validation Set Results

	Number of Patients	10-year Disease-Specific Survival (%)	Adjusted Hazard Ratio (95% CI)	P-value	10-year Overall Survival (%)	Adjusted Hazard Ratio (95% CI)	P-value
Training Set Patients	190
Fractal dimension
< 1.56	68	69.4	1.0		66.2	1.0
1.56 - 1.75	76	52.3	2.4 (0.1, 5.8)	0.064	34.2	2.2 (1.0, 4.8)	0.050
>1.75	46	17.0	2.5 (1.0, 6.3)	0.056	16.5	1.8 (0.8, 4.1)	0.17
Validation Set Patients	189
Fractal dimension
< 1.56	73	71.6	1.0		70.6	1.0
1.56 - 1.75	72	60.5	1.3 (0.6, 3.3)	0.51	44.8	1.7 (0.8, 3.9)	0.18
>1.75	44	32.4	2.3 (1.0, 5.5)	0.06	11.2	3.2 (1.5, 6.9)	0.003

AUC adjusted disease-specific survival analysis, training set = 0.72, validation set = 0.73
AUC adjusted overall survival analysis, training set = 0.68, validation set = 0.73

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