Bevacizumab treatment improved survival and decreased tumor growth in nude mice bearing Tsc2-/- tumors. (a) Average tumor volume over time for bevacizumab and bevacizumab plus rapamycin treated animals. (b) Survival curve for indicated treatment cohorts. Based on survival analysis and comparison of tumor volumes on day 30, bevacizumab improves survival and decreases tumor growth compared to the untreated cohort. Bevacizumab is not as effective as single agent rapamycin in improving survival or decreasing tumor growth. Based on analysis and comparisons of tumor volumes on day 65, bevacizumab in combination with rapamycin provided no improvement over single agent rapamycin treatment.