Table 1 Cases of elevated plasma creatinine levels in children who received intravenous acyclovir
From: The effect of acyclovir on the tubular secretion of creatinine in vitro
Patient | Magnitude of increase in plasma creatinine (from baseline) | Relevant clinical details | References |
|---|---|---|---|
1 child | 5 fold increase within 2 days | Creatinine returned to normal in 4 days Elevated urea No other pathology reported | [4] |
10 children | transient elevation | No further impairment reported | [2] |
3 children | 4 fold increase within 4 days | Mild reduction in urine output Creatinine returned to normal 1 week following acyclovir discontinuation | [3] |
1 child | 2 fold increase within 6 days | Creatinine continued to increase following acyclovir discontinuation. Creatinine returned to normal within 1 week Elevated urea Mild proteinuria | [7] |
3 children | 9 fold increase within 2 to 3 days | High urea Urinary α1-microglobulin and albumin Creatinine returned to normal in 3 - 9 days | [8] |
1 child | 3 fold increase within 4 days | No other information provided | [5] |