From: Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer
 | Simonetti et al | Ilie et al[19] | Kato et al[20] | Kitamura et al[22] | Brevet et al[14] | Yu et al[12] | Kawahara et al[21] |
---|---|---|---|---|---|---|---|
Total cases | 78 | 61 | 70 | 343 | 194 | 340 | 60 |
Age, years | Â | Â | Â | Â | Â | Â | Â |
range | 36-85 | 42-83 | 27-88 | Â | Â | Â | Â |
median | 64 | 67 | 59.9 | Â | Â | Â | Â |
Sex | Â | Â | Â | Â | Â | Â | Â |
male | 28 | 31 | 36 | Â | Â | Â | Â |
female | 50 | 30 | 34 | Â | Â | Â | Â |
Ethnicity | Â | Â | Â | Â | Â | Â | Â |
Caucasian | 78 | 61 | 0 | 0 | Â | Â | 0 |
Asian | 0 | 0 | 70 | 343 | Â | Â | 60 |
Smoking history | Â | Â | Â | Â | Â | Â | Â |
smokers | 33 | 37 | 41 | Â | Â | Â | Â |
non-smokers | 45 | 24 | 29 | Â | Â | Â | Â |
Histology | Â | Â | Â | Â | Â | Â | Â |
adeno | 69 | 61 | 57 | Â | Â | 217 | 60 |
SCC | 1 | 0 | 7 | Â | Â | 112 | 0 |
LCC | 5 | 0 | 4 | Â | Â | 11 | 0 |
others | 3 | 0 | 2 | Â | Â | 0 | 0 |
EGFR | Â | Â | Â | Â | Â | Â | Â |
exon 19 | 29 | 10 | 18 | 21 | 55 | 58 | 21 |
exon21 | 27 | 0 | 12 | 14 | 18 | 56 | 23 |
wild-type | 22 | 51 | 29 | 296 | 145 | 167 | 16 |
IHC sensitivity | Â | Â | Â | Â | Â | Â | Â |
overall | Â | Â | Â | Â | Â | 92% | Â |
delE746-A750 Ab | 63% | 22.86% | 81.1% | 99% | 84.6% | Â | 79% |
l858r Ab | 100% | Â | 75% | 97% | 95.2% | Â | 83% |
IHC specificity | Â | Â | Â | Â | Â | Â | Â |
overall | Â | Â | Â | Â | Â | 99% | Â |
delE746-A750 Ab | 100% | 92% | 100% | 40% | 98.8% | Â | Â |
L858R Ab | 100% | Â | 96.6% | 36% | 98.8% | Â | Â |