Skip to main content

Table 4 Patient characteristics and EGFR mutation status in seven studies examining EGFR mutations by IHC. (Blank cells indicate that information is not available.)

From: Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer

 

Simonetti et al

Ilie et al[19]

Kato et al[20]

Kitamura et al[22]

Brevet et al[14]

Yu et al[12]

Kawahara et al[21]

Total cases

78

61

70

343

194

340

60

Age, years

       

range

36-85

42-83

27-88

    

median

64

67

59.9

    

Sex

       

male

28

31

36

    

female

50

30

34

    

Ethnicity

       

Caucasian

78

61

0

0

  

0

Asian

0

0

70

343

  

60

Smoking history

       

smokers

33

37

41

    

non-smokers

45

24

29

    

Histology

       

adeno

69

61

57

  

217

60

SCC

1

0

7

  

112

0

LCC

5

0

4

  

11

0

others

3

0

2

  

0

0

EGFR

       

exon 19

29

10

18

21

55

58

21

exon21

27

0

12

14

18

56

23

wild-type

22

51

29

296

145

167

16

IHC sensitivity

       

overall

     

92%

 

delE746-A750 Ab

63%

22.86%

81.1%

99%

84.6%

 

79%

l858r Ab

100%

 

75%

97%

95.2%

 

83%

IHC specificity

       

overall

     

99%

 

delE746-A750 Ab

100%

92%

100%

40%

98.8%

  

L858R Ab

100%

 

96.6%

36%

98.8%

 Â