Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer

Table 4 Patient characteristics and EGFR mutation status in seven studies examining EGFR mutations by IHC. (Blank cells indicate that information is not available.)

	Simonetti et al	Ilie et al[19]	Kato et al[20]	Kitamura et al[22]	Brevet et al[14]	Yu et al[12]	Kawahara et al[21]
Total cases	78	61	70	343	194	340	60
Age, years
range	36-85	42-83	27-88
median	64	67	59.9
Sex
male	28	31	36
female	50	30	34
Ethnicity
Caucasian	78	61	0	0			0
Asian	0	0	70	343			60
Smoking history
smokers	33	37	41
non-smokers	45	24	29
Histology
adeno	69	61	57			217	60
SCC	1	0	7			112	0
LCC	5	0	4			11	0
others	3	0	2			0	0
EGFR
exon 19	29	10	18	21	55	58	21
exon21	27	0	12	14	18	56	23
wild-type	22	51	29	296	145	167	16
IHC sensitivity
overall						92%
delE746-A750 Ab	63%	22.86%	81.1%	99%	84.6%		79%
l858r Ab	100%		75%	97%	95.2%		83%
IHC specificity
overall						99%
delE746-A750 Ab	100%	92%	100%	40%	98.8%
L858R Ab	100%		96.6%	36%	98.8%

ISSN: 1479-5876