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Table 4 Patient characteristics and EGFR mutation status in seven studies examining EGFR mutations by IHC. (Blank cells indicate that information is not available.)

From: Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer

  Simonetti et al Ilie et al[19] Kato et al[20] Kitamura et al[22] Brevet et al[14] Yu et al[12] Kawahara et al[21]
Total cases 78 61 70 343 194 340 60
Age, years        
range 36-85 42-83 27-88     
median 64 67 59.9     
Sex        
male 28 31 36     
female 50 30 34     
Ethnicity        
Caucasian 78 61 0 0    0
Asian 0 0 70 343    60
Smoking history        
smokers 33 37 41     
non-smokers 45 24 29     
Histology        
adeno 69 61 57    217 60
SCC 1 0 7    112 0
LCC 5 0 4    11 0
others 3 0 2    0 0
EGFR        
exon 19 29 10 18 21 55 58 21
exon21 27 0 12 14 18 56 23
wild-type 22 51 29 296 145 167 16
IHC sensitivity        
overall       92%  
delE746-A750 Ab 63% 22.86% 81.1% 99% 84.6%   79%
l858r Ab 100%   75% 97% 95.2%   83%
IHC specificity        
overall       99%  
delE746-A750 Ab 100% 92% 100% 40% 98.8%   
L858R Ab 100%   96.6% 36% 98.8%