Figure 9

Macroscopic and histopathological views of the orthotopic bladders treated with H19-DTA-P4-DTA: Shown are macroscopic photographs of the whole orthotopic bladders treated with H19-Luc-P4-Luc (A), or with H19-DTA-P4-DTA (D). The bladders of both of the groups were excised, and the area of the malignant tissue of each bladder is indicated (by grin line) for the H19-Luc-P4-Luc (B) and H19-DTA-P4-DTA (E). Histopathological microscopic view (H&E × 10 is shown for H19-Luc-P4-Luc treated bladder (C), or with H19-DTA-P4-DTA treated bladder (F) and the tumor areas are indicated (by green line), ('U', urothelium,'LP', lamina propria, 'M', muscle).