Figure 8

The effect of intravesical treatment with H19-DTA-P4-DTA vector in orthotopic bladder carcinoma: Orthotopic tumors were induced by intravesical instillation of T24P cells, in nude mice bladders. 7 days later, mice of each group (n = 6) received an intravesical treatment with 20 μg of H19-DTA-P4-DTA, or H19-Luc-P4-Luc for each mouse. The same treatments were repeated after 3 days, and 4 days later mice were sacrificed. The bladders of both groups were excised, weighted, and the area of the malignant tissue of each bladder was determined by ImagePro Plus software. Another 4 healthy mice were used as control. The total tumor area of each bladder was determined and the mean of the total areas was calculated for each group. The Mean and SD of bladder tumor area (A) and weight (B) are shown.