Figure 5

In vivo inhibition of heterotopic tumors in response to H19-DTA-P4-DTA treatments. Inhibition of tumor growth in response to H19-DTA, P4-DTA, or H19-DTA-P4-DTA treatments is shown. The tumor sizes of tumors treated with the DTA expressing vector, or with control luciferase expressing vectors were determined prior to each treatment and before sacrifice. The fold increase in tumor volume was calculated relative to the initial volume at the day of the first treatment.