Figure 12From: Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequencesAugmented-than-additive activity of H19-DTA-P4-DTA in heterotopic bladder tumors, induced by T24P cells. The inhibition of heterotopic bladder tumor growth, induced by T24P cells is indicated by the fold increase of each DTA mice treated group compared to the control Luc treated mice. Shown are tumors treated with: 25 μg of H19-DTA, 25 μg of P4-DTA, 25 μg of H19-DTA + 25 μg of P4-DTA 25 μg of H19-DTA-P4-DTA and 50 μg of H19-DTA-P4-DTA.Back to article page