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Table 3 Multivariate analyses of factors associated with OS and LMFS

From: The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer

Variable OS (n = 98) LMFS (n = 98)
  HR, (95% CI) P value HR, (95% CI) P value
Gender (female vs. male) 1.954 (0.841-4.538) 0.119 0.333 (0.083-1.335) 0.121
Age (< 60 y vs. ≥ 60 y) 0.504 (0.227-1.116) 0.091 0.881 (0.267-2.906) 0.835
Invasive depth (T4 vs. T3) 1.941 (0.693-5.436) 0.207 0.846 (0.171-4.190) 0.838
Site of primary tumors (right vs. left) 2.184 (0.981-4.859) 0.056 1.009 (0.298-3.414) 0.989
Grade (G3 vs. G2 vs. G1) 1.224 (0.457-3.281) 0.688 1.616 (0.345-7.575) 0.543
Pathologic Classification (mucoid + signet ring vs. papillary + tubular) 2.364 (0.787-7.100) 0.125 0.537 (0.071-4.061) 0.547
Growth patterns (infiltrating vs. pushing) 0.700 (0.295-1.662) 0.419 2.650 (0.551-12.746) 0.224
CD68TFHotspot group (high vs. low) 0.433 (0.194-0.966) 0.041* 0.265 (0.078-0.900) 0.033*
Liver metastasis (yes vs. no) 8.144 (3.276-20.250) 0.000** NA NA
  1. Multivariate analysis, Cox proportional hazard regression model. Abbreviations: HR, hazard ratio; CI, confidence interval; NA, not assessment. *: p < 0.05; **: p < 0.001.