The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer

Table 3 Multivariate analyses of factors associated with OS and LMFS

Variable	OS (n = 98)		LMFS (n = 98)
	HR, (95% CI)	P value	HR, (95% CI)	P value
Gender (female vs. male)	1.954 (0.841-4.538)	0.119	0.333 (0.083-1.335)	0.121
Age (< 60 y vs. ≥ 60 y)	0.504 (0.227-1.116)	0.091	0.881 (0.267-2.906)	0.835
Invasive depth (T4 vs. T3)	1.941 (0.693-5.436)	0.207	0.846 (0.171-4.190)	0.838
Site of primary tumors (right vs. left)	2.184 (0.981-4.859)	0.056	1.009 (0.298-3.414)	0.989
Grade (G3 vs. G2 vs. G1)	1.224 (0.457-3.281)	0.688	1.616 (0.345-7.575)	0.543
Pathologic Classification (mucoid + signet ring vs. papillary + tubular)	2.364 (0.787-7.100)	0.125	0.537 (0.071-4.061)	0.547
Growth patterns (infiltrating vs. pushing)	0.700 (0.295-1.662)	0.419	2.650 (0.551-12.746)	0.224
CD68TF_Hotspot group (high vs. low)	0.433 (0.194-0.966)	0.041*	0.265 (0.078-0.900)	0.033*
Liver metastasis (yes vs. no)	8.144 (3.276-20.250)	0.000**	NA	NA

Multivariate analysis, Cox proportional hazard regression model. Abbreviations: HR, hazard ratio; CI, confidence interval; NA, not assessment. *: p < 0.05; **: p < 0.001.