The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer

Table 2 Univariate analyses of factors associated with OS and LMFS.

Variable	OS (n = 98)		LMFS (n = 98)
	HR, (95% CI)	P value	HR, (95% CI)	P value
Gender (female vs. male)	1.157 (0.562-2.381)	0.693	0.416 (0.114-1.510)	0.182
Age (< 60 y vs. ≥ 60 y)	0.732 (0.352-1.519)	0.402	0.704 (0.230-2.153)	0.538
Invasive depth (T4 vs. T3)	1.023 (0.392-2.674)	0.962	0.902 (0.200-4.068)	0.893
Sites of primary tumors (right vs. left)	2.271 (1.093-4.717)	0.028*	0.815 (0.267-2.491)	0.720
Grade (G3 vs. G2 vs. G1)	1.519 (0.715-3.224)	0.277	1.036 (0.324-3.311)	0.953
Pathologic classification (mucoid + signet ring vs. papillary + tubular)	2.415 (1.129-5.168)	0.023*	1.148 (0.316-4.171)	0.834
Growth pattern (infiltrating vs. pushing)	0.817 (0.389-1.718)	0.595	2.709 (0.600-12.223)	0.195
CD68TF_Hotspot (4 vs. 3 vs. 2 vs.1)	0.568 (0.393-0.822)	0.003*	0.594 (0.344-1.025)	0.061
CD68TF_Hotspot group (high vs. low)	0.288 (0.139-0.600)	0.001*	0.324 (0.106-0.991)	0.048*
Hepatic metastasis (yes vs. no)	5.852 (2.737-12.511)	0.000**	NA	NA

Univariate analysis, Cox proportional hazards regression model. Abbreviations: HR, hazard ratio; CI, confidence interval; NA, not assessment. *: p < 0.05; **: p < 0.001.

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