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Table 1 Effect of NSC23766 on P-selectin expression of platelets in blood stimulated by TRAP and collagen

From: Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque

Agonist P-selectin expression (% positive cells)
  Control Stimulated
TRAP (5 μM) 1.6 ± 0.6 6.8 ± 3.4
TRAP+NSC23766 (300 μM)   1.4 ± 0.6
Collagen (5 μg/ml) 1.7 ± 0.9 8 ± 2.6
Collagen+NSC23766 (300 μM)   2.9 ± 2
  1. Blood was incubated with NSC23766 (300 μM) or solvent (water) in the presence of 2 mM RGDS for 5 min whilst stirring at 37°C before stimulation with TRAP or collagen. P-selectin expression was measured by flow cytometry. Values are mean ± SD, n = 3.