Figure 4
Effect of NSC23766 on atherosclerotic plaque-induced platelet thrombus formation under arterial flow conditions. Hirudin-anticoagulated blood pre-incubated with H2O or with NSC23766 (300 μM) for 5 min was perfused over plaque-coated surfaces for 10 min at 37°C at a shear rate of 1500 s-1. (A) representative flow images of control (upper channel) and NSC23766 treated blood (lower channel) 10 min after start of the flow; Platelets are visualized by mepacrine fluorescence; (B) bar diagram (values are mean ± SD; n = 5). * p < 0.002.