TY - JOUR AU - Fernandez-Ortiz, A. AU - Badimon, J. J. AU - Falk, E. AU - Fuster, V. AU - Meyer, B. AU - Mailhac, A. AU - Weng, D. AU - Shah, P. K. AU - Badimon, L. PY - 1994 DA - 1994// TI - Characterization of the relative thrombogenicity of atherosclerotic plaque components: implications for consequences of plaque rupture JO - J Am Coll Cardiol VL - 23 UR - https://doi.org/10.1016/0735-1097(94)90657-2 DO - 10.1016/0735-1097(94)90657-2 ID - Fernandez-Ortiz1994 ER - TY - JOUR AU - Vanzanten, G. H. AU - Degraaf, S. AU - Slootweg, P. J. AU - Heijnen, H. F. G. AU - Connolly, T. M. AU - Degroot, P. G. AU - Sixma, J. J. PY - 1994 DA - 1994// TI - Increased Platelet Deposition on Atherosclerotic Coronary-Arteries JO - Journal of Clinical Investigation VL - 93 UR - https://doi.org/10.1172/JCI117014 DO - 10.1172/JCI117014 ID - Vanzanten1994 ER - TY - JOUR AU - Siess, W. AU - Zangl, K. J. AU - Essler, M. AU - Bauer, M. AU - Brandl, R. AU - Corrinth, C. AU - Bittman, R. AU - Tigyi, G. AU - Aepfelbacher, M. PY - 1999 DA - 1999// TI - Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions JO - Proceedings of the National Academy of Sciences of the United States of America VL - 96 UR - https://doi.org/10.1073/pnas.96.12.6931 DO - 10.1073/pnas.96.12.6931 ID - Siess1999 ER - TY - JOUR AU - Rother, E. AU - Brandl, R. AU - Baker, D. L. AU - Goyal, P. AU - Gebhard, H. AU - Tigyi, G. AU - Siess, W. PY - 2003 DA - 2003// TI - Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques JO - Circulation VL - 108 UR - https://doi.org/10.1161/01.CIR.0000083715.37658.C4 DO - 10.1161/01.CIR.0000083715.37658.C4 ID - Rother2003 ER - TY - JOUR AU - Penz, S. AU - Reininger, A. J. AU - Brandl, R. AU - Goyal, P. AU - Rabie, T. AU - Bernlochner, I. AU - Rother, E. AU - Goetz, C. AU - Engelmann, B. AU - Smethurst, P. A. PY - 2005 DA - 2005// TI - Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI JO - FASEB J VL - 19 UR - https://doi.org/10.1096/fj.04-2748com DO - 10.1096/fj.04-2748com ID - Penz2005 ER - TY - JOUR AU - Reininger, A. J. AU - Bernlochner, I. AU - Penz, S. M. AU - Ravanat, C. AU - Smethurst, P. AU - Farndale, R. W. AU - Gachet, C. AU - Brandl, R. AU - Siess, W. PY - 2010 DA - 2010// TI - A 2Step Mechanism of Arterial Thrombus Formation Induced by Human Atherosclerotic Plaques JO - Journal of the American College of Cardiology VL - 55 UR - https://doi.org/10.1016/j.jacc.2009.11.051 DO - 10.1016/j.jacc.2009.11.051 ID - Reininger2010 ER - TY - JOUR AU - Bauer, M. AU - Retzer, M. AU - Wilde, J. I. AU - Maschberger, P. AU - Essler, M. AU - Aepfelbacher, M. AU - Watson, S. P. AU - Siess, W. PY - 1999 DA - 1999// TI - Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets JO - Blood VL - 94 ID - Bauer1999 ER - TY - JOUR AU - Klages, B. AU - Brandt, U. AU - Simon, M. I. AU - Schultz, G. AU - Offermanns, S. PY - 1999 DA - 1999// TI - Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets JO - J Cell Biol VL - 144 UR - https://doi.org/10.1083/jcb.144.4.745 DO - 10.1083/jcb.144.4.745 ID - Klages1999 ER - TY - JOUR AU - McCarty, O. J. AU - Larson, M. K. AU - Auger, J. M. AU - Kalia, N. AU - Atkinson, B. T. AU - Pearce, A. C. AU - Ruf, S. AU - Henderson, R. B. AU - Tybulewicz, V. L. AU - Machesky, L. M. AU - Watson, S. P. PY - 2005 DA - 2005// TI - Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M504672200 DO - 10.1074/jbc.M504672200 ID - McCarty2005 ER - TY - JOUR AU - Soulet, C. AU - Gendreau, S. AU - Missy, K. AU - Benard, V. AU - Plantavid, M. AU - Payrastre, B. PY - 2001 DA - 2001// TI - Characterisation of Rac activation in thrombin- and collagen-stimulated human blood platelets JO - FEBS Lett VL - 507 UR - https://doi.org/10.1016/S0014-5793(01)02984-2 DO - 10.1016/S0014-5793(01)02984-2 ID - Soulet2001 ER - TY - JOUR AU - Gratacap, M. P. AU - Payrastre, B. AU - Nieswandt, B. AU - Offermanns, S. PY - 2001 DA - 2001// TI - Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides JO - J Biol Chem VL - 276 ID - Gratacap2001 ER - TY - JOUR AU - Akbar, H. AU - Kim, J. AU - Funk, K. AU - Cancelas, J. A. AU - Shang, X. AU - Chen, L. AU - Johnson, J. F. AU - Williams, D. A. AU - Zheng, Y. PY - 2007 DA - 2007// TI - Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation JO - J Thromb Haemost VL - 5 UR - https://doi.org/10.1111/j.1538-7836.2007.02646.x DO - 10.1111/j.1538-7836.2007.02646.x ID - Akbar2007 ER - TY - JOUR AU - Pandey, D. AU - Goyal, P. AU - Dwivedi, S. AU - Siess, W. PY - 2009 DA - 2009// TI - Unraveling a novel Rac1-mediated signaling pathway that regulates cofilin dephosphorylation and secretion in thrombin-stimulated platelets JO - Blood VL - 114 UR - https://doi.org/10.1182/blood-2008-10-183582 DO - 10.1182/blood-2008-10-183582 ID - Pandey2009 ER - TY - JOUR AU - Pleines, I. AU - Elvers, M. AU - Strehl, A. AU - Pozgajova, M. AU - Varga-Szabo, D. AU - May, F. AU - Chrostek-Grashoff, A. AU - Brakebusch, C. AU - Nieswandt, B. PY - 2009 DA - 2009// TI - Rac1 is essential for phospholipase C-gamma2 activation in platelets JO - Pflugers Arch VL - 457 UR - https://doi.org/10.1007/s00424-008-0573-7 DO - 10.1007/s00424-008-0573-7 ID - Pleines2009 ER - TY - JOUR AU - Gao, Y. AU - Dickerson, J. B. AU - Guo, F. AU - Zheng, J. AU - Zheng, Y. PY - 2004 DA - 2004// TI - Rational design and characterization of a Rac GTPase-specific small molecule inhibitor JO - Proc Natl Acad Sci USA VL - 101 UR - https://doi.org/10.1073/pnas.0307512101 DO - 10.1073/pnas.0307512101 ID - Gao2004 ER - TY - JOUR AU - Brandl, R. AU - Richter, T. AU - Haug, K. AU - Wilhelm, M. G. AU - Maurer, P. C. AU - Nathrath, W. PY - 1997 DA - 1997// TI - Topographic analysis of proliferative activity in carotid endarterectomy specimens by immunocytochemical detection of the cell cycle-related antigen Ki-67 JO - Circulation VL - 96 UR - https://doi.org/10.1161/01.CIR.96.10.3360 DO - 10.1161/01.CIR.96.10.3360 ID - Brandl1997 ER - TY - JOUR AU - Penz, S. M. AU - Reininger, A. J. AU - Toth, O. AU - Deckmyn, H. AU - Brandl, R. AU - Siess, W. PY - 2007 DA - 2007// TI - Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques JO - Thromb Haemost VL - 97 ID - Penz2007 ER - TY - JOUR AU - Toth, O. AU - Calatzis, A. AU - Penz, S. AU - Losonczy, H. AU - Siess, W. PY - 2006 DA - 2006// TI - Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood JO - Thromb Haemost VL - 96 ID - Toth2006 ER - TY - JOUR AU - Ingerman, C. M. AU - Smith, J. B. AU - Silver, M. J. PY - 1979 DA - 1979// TI - Direct measurement of platelet secretion in whole blood JO - Thromb Res VL - 16 UR - https://doi.org/10.1016/0049-3848(79)90081-1 DO - 10.1016/0049-3848(79)90081-1 ID - Ingerman1979 ER - TY - JOUR AU - Saniabadi, A. R. AU - Lowe, G. D. AU - Belch, J. J. AU - Barbenel, J. C. AU - Forbes, C. D. PY - 1984 DA - 1984// TI - Effect of prostacyclin (epoprostenol) on the aggregation of human platelets in whole blood in vitro JO - Haemostasis VL - 14 ID - Saniabadi1984 ER - TY - JOUR AU - Azim, A. C. AU - Barkalow, K. AU - Chou, J. AU - Hartwig, J. H. PY - 2000 DA - 2000// TI - Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor JO - Blood VL - 95 ID - Azim2000 ER - TY - JOUR AU - Soulet, C. AU - Hechler, B. AU - Gratacap, M. P. AU - Plantavid, M. AU - Offermanns, S. AU - Gachet, C. AU - Payrastre, B. PY - 2005 DA - 2005// TI - A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation JO - J Thromb Haemost VL - 3 UR - https://doi.org/10.1111/j.1538-7836.2005.01588.x DO - 10.1111/j.1538-7836.2005.01588.x ID - Soulet2005 ER - TY - JOUR AU - Cho, M. J. AU - Liu, J. AU - Pestina, T. I. AU - Steward, S. A. AU - Thomas, D. W. AU - Coffman, T. M. AU - Wang, D. AU - Jackson, C. W. AU - Gartner, T. K. PY - 2003 DA - 2003// TI - The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation JO - Blood VL - 101 UR - https://doi.org/10.1182/blood-2002-05-1363 DO - 10.1182/blood-2002-05-1363 ID - Cho2003 ER - TY - JOUR AU - Rinder, C. S. AU - Student, L. A. AU - Bonan, J. L. AU - Rinder, H. M. AU - Smith, B. R. PY - 1993 DA - 1993// TI - Aspirin does not inhibit adenosine diphosphate-induced platelet alpha-granule release JO - Blood VL - 82 ID - Rinder1993 ER - TY - JOUR AU - Siess, W. PY - 1989 DA - 1989// TI - Molecular mechanisms of platelet activation JO - Physiol Rev VL - 69 ID - Siess1989 ER -